Glutamate carboxypeptidase 2 (FOLH1) Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
NCT04633148 -
Breast Cancer, Colorectal Cancer, Renal Cancer, Prostate Cancer
NCT03356795 -
Cervical Cancer
NCT04249947 -
Prostate Cancer
NCT01140373 -
Prostate Cancer
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present.