Description

Glutamate carboxypeptidase 2 (FOLH1) Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.


Clinical trials

NCT04633148 - Breast Cancer, Colorectal Cancer, Renal Cancer, Prostate Cancer
NCT03356795 - Cervical Cancer
NCT04249947 - Prostate Cancer
NCT01140373 - Prostate Cancer


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene FOLH1.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present.